Wan
said the goal of his research is to find the sources of human H5N1 infections
and provide the foundations for policy-making for protecting public health.
While the United States has regulations in place to protect consumers, this is
not the case in all countries
A Mississippi State University researcher has
uncovered the first molecular evidence linking live poultry markets in China to
human H5N1 avian influenza.
Henry Wan, an assistant professor in systems
biology at MSU’s College of Veterinary Medicine, collaborated with scientists
in the World Health Organization Collaborative Centers for Influenza in China
and St. Jude Children’s Research Hospital to investigate the connection.
“Although conceptually we knew live bird
markets posed a risk for human H5N1 infection, there had previously not been
any direct evidence, especially molecular evidence, supporting this
hypothesis,” Wan said.
Based on information provided by patients
infected with the H5N1 virus during the 2008-2009 season, Wan and his
colleagues collected and analyzed 69 environmental samples from the live bird
markets visited by six patients before the onset of the disease.
“From these 69 samples, we isolated a total of
12 highly pathogenic H5N1 avian influenza viruses from four of the six live
bird markets. The similarity of the genetic sequence of the environmental and
corresponding human isolates demonstrates a solid link between human infection
and live poultry markets,” Wan said.
Wan said the goal of his research is to find
the sources of human H5N1 infections and provide the foundations for
policy-making for protecting public health. While the United States has
regulations in place to protect consumers, this is not the case in all
countries.
Wan began studying avian influenza while
conducting graduate work in southern China in 1996. He was the first scientist
to identify the highly pathogenic H5N1 avian influenza virus. One year later,
this virus infected humans in Hong Kong, resulting in six deaths.
The subsequent massive depopulation of poultry
stopped the human outbreak for a time, but two cases identified in Hong Kong in
2003 confirmed the virus was still circulating in the region and posed a health
hazard. From 2003 to 2011, the World Health Organization recorded a total of
566 confirmed human cases for avian influenza worldwide that have resulted in
332 deaths. To date, there have not been any highly pathogenic H5N1 detections
in the United States.
Wan, whose other area of expertise is
developing computer programs to model the mutation of viruses and to identify
vaccine strains, performed an evolutionary study on this virus to identify the
links between the human and avian strains of the virus at the molecular level.
“H5N1 viruses have spread to both wild and
domestic bird populations in many countries, predominately in Asia, Africa and
Europe,” Wan said.
Although no sustained human-to-human
transmissions of the H5N1 virus have been confirmed, the mortality rate among
human cases to date is about 60 percent.
Wan hopes the results of this study can be
used to develop policies to prevent and control H5N1 infections in humans.
“For instance, control and regulations of live
bird markets could be used to help prevent the H5N1 human infections in areas
that have active live bird markets,” he said.
In the United States, most live bird markets
are in major metropolitan areas.
“We have live bird markets in many major
cities with large concentrations of ethnic groups who prefer to buy live
poultry rather than processed poultry,” said CVM’s Dr. Danny Magee, director of
the Poultry Research and Diagnostic Laboratory in Pearl. “The U.S. Department
of Agriculture’s Animal and Plant Health Inspection Service has monitoring
procedures in place to prevent and control the disease in live bird markets and
in the production premises and poultry distributors that supply those markets.”
Magee said Mississippi’s commercial poultry
industry follows biosecurity protocols to protect the chickens on the farms
from avian influenza.
“Raising chickens in confinement minimizes
their exposure to wild migratory waterfowl, which have been identified as
possible reservoirs of the avian influenza virus,” he said. “Biosecurity
practices also limit exposure of the chickens to unauthorized visitors on the
farm. The flocks are raised as securely as possible, and then they are tested
for exposure to the avian influenza virus before they are sent to market. Every
flock in the state undergoes this serological test so the consumer can be assured
that the product is safe.”
Poultry is Mississippi’s top agricultural
commodity, with a 2011 production value of $2.21 billion.
“Approximately 15 million broilers are
processed in Mississippi each week,” Magee said. “We test the breeders that lay
the eggs to produce the broilers, and we test the commercial egg-laying birds.
The facility in Pearl is one of the labs in the Southeast that performs the
regulatory test to monitor for the presence of the avian influenza virus in the
commercial poultry industry.”
Keri Collins Lewis
MSU Ag Communications
Delta Farm Press
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