Showing posts with label Osteoporosis. Show all posts
Showing posts with label Osteoporosis. Show all posts

Mar 6, 2012

Japan - Excessive vitamin E leads to osteoporosis?


TOKYO: Japanese scientists say they have found a link between consumption of vitamin E and the degenerative bone condition osteoporosis, in a study likely to shed new light on the use of supplements.

Researchers found that giving mice increased doses of the vitamin to a level similar to that found in supplements caused the animals' bones to thin.

The mice developed osteoporosis after eight weeks on the diet, which had levels of vitamin E significantly higher than those found in a mouse's natural diet, according to the study, published in the journal Nature Medicine.

The team, led by Shu Takeda of Keio University, said vitamin E stimulates the generation of bone-degrading cells, which normally work with bone-forming cells to maintain bone strength.

Osteoporosis is a disease that causes the thinning of bone tissue and loss of bone density over time. It often affects older people, particularly women, who may become more prone to bone fractures.

Vitamin E is found naturally in various foods including vegetable oil, nuts and some leafy vegetables.

It is also a popular health supplement as an antioxidant, and is widely believed to enhance health and slow problems related to ageing.

The study called for greater research into how enhanced levels of vitamin E affect human health.

"It is possible that with the volume (of vitamin E) contained in health supplements, bones may become fragile," Takeda told the Mainichi Shimbun newspaper.

The findings come after researchers found mice that had been genetically modified to be deficient in vitamin E had a high bone density.


- AFP/fa


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Nov 7, 2011

Malaysia - Drop sedentary lifestyle to avoid osteoporosis



KUALA LUMPUR: The modern lifestyle that literally means a sedentary lifestyle to most people today is the source of numerous health woes.

Life goes by sitting and watching television, reading, idling, sleeping, spending hours in front of the computer, eating and indulging in video games, all without much mobility.
Routine exercise and outdoor activities seem to be the privilege of a few.

A recent study provided a clearer snapshot of Malaysians’ sedentary ways with three out of every four Malaysians doing more mental work than physical work.

This already unhealthy lifestyle is further compounded by the fact many Malaysians prefer food rich in fats and cholesterol and less in fiber – beef/lamb steak, pizza with different layers of cheese or the pasta.
With better life expectancy, thanks to modern medicine, Malaysia will have 3.4 million people above 60 by 2020 and this is a cause of concern as many Malaysians are leading a unhealthy lifestyle now and the implications will be seen when they get older.

Why awareness on good health is important

Malaysians have every reason to worry over their unhealthy lifestyle that makes them vulnerable to ailments, and especially when healthcare is getting costlier as time goes by.

One of the outcome of an unhealthy lifestyle that manifests at old age is osteoporosis.

Osteoporosis, that literally means brittle bones, is difficult to detect until someone breaks a hip bone or the backbone, the obvious symptom of the disease.

Dr Chin Chee Howe, an Orthopedic and Trauma surgeon noted that even a bone inspection x-ray would not be able to detect the problem until the bones shed up to 50 percent of their mass.

Dr Chin explained that the human body regardless of the age needs constant supply of calcium especially when looking at the fact that bones are living tissues that reabsorb the calcium and resynthesize new bones.

High risk women

Women face three times greater risk than men in suffering from osteoporosis, and thus it is pertinent that this group reviewed their unhealthy lifestyle.

In the natural state, women have less calcium in their bone and thus their bone mass is much lesser. They lose calcium due to unhealthy habits like smoking, eating less to keep their body shape or even due to pregnancy and menopause.

Longer life expectancy also contributes to the problem.

“Studies found that women in their late 60s with broken hip bones face five times greater mortality risk within a year due to the bones breaking or blood clot problems,” explained Dr Chin.

However, the reduction of bone mass is expected to continue and by 2050 more than 50 per cent of hip bone fractures are expected to occur in Asia.

“And it is going to be a big problem when looking at the high cost in managing and treating broken bones, thus it is important to draw up early strategy and carry out proactive steps in preserving their bones,” said Chin adding the age old adage prevention is better than cure to his remark.

Go on a healty life style

Life is definitely going to be tough for those who break their bones due to osteoporosis, ending up wheel-chair bound or bed-ridden?     

So the best thing to do is to take preventive steps early.

Good diet and routine exercise helps one to attain the maximum bone mass by the age of 30.

The balanced diet that includes sufficient calcium, added with Vitamin D through the safe exposure to sunlight, magnesium from green vegetables and regular exercise help women in keeping away from the bone ravaging disease.

Dr Chin proposed the easiest exercise to strengthen the bones – a brisk walk for 30 minutes daily or carry weight to help in the natural bone building process, other than consuming high calcium milk and dairy products.

“Physical activities are important to build and preserve bone mass to enable us to use the full potential of our bones, apart from rejuvenating our physical and mental health,” he stressed pointing out that high calcium milk and low fat yogurt are the best choice for women.

Nutritient for bones

Speaking on calcium intake, Dr Chin suggested that calcium rich food is more effective than the vast array of calcium supplements available in the market with magnesium and vitamin D that helps in the absorption of calcium.

The food that holds the key to good bone health are diary products, green vegetables, soy bean products like tofu and tempe, fish like sardine, salmon and tuna, and marine food.
What is more important is that everyone has to be aware of the health issues in old age and take preventive actions early.

Meanwhile, studies conducted by a leading diary firm from New Zealand, Fonterra, found that a significant number of Malaysian women are aware on why calcium is important to health but harbour the wrong notion that it is too early for them to worry over it.

However, Fonterra continues its campaign with its improved Anlene products from time to time including the latest product Anlene Concentrate, milk in a small carton with high calcium content compared with fresh milk.

Bernama



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Oct 12, 2011

Taiwan - Taiwanese research team finds new key to treating osteoporosis


A National Cheng Kung University (NCKU) research team has identified a protein that it described as a key to treating osteoporosis, a disease that lowers a person's bone density, the southern Taiwan university said.

Chang Ming-shi, a professor at NCKU's Department of Biochemistry and Molecular Biology, said the protein, called interleukin (IL)-20, is found in higher than normal amounts in the blood of osteoporosis patients, suggesting that IL-20 is involved in the progression of the disease.

The professor described the finding as a "revolutionary discovery" because the association between IL-20 - which is secreted by the immune system - and osteoporosis had never been explored.

According to Chang, there are two types of bone cells - osteoclasts and osteoblasts - and bone mineral density is determined by the balance between the two.

Osteoclasts promote a decrease in bone mass and osteoblasts form bone. Osteoporosis results when osteoclasts break down bones faster than osteoblasts can rebuild them.

Chang and her team found that IL-20 stimulates the formation of osteoclasts by increasing the amount of two proteins - RANK on osteoclasts and RANKL on osteoblasts - that are instrumental in bone metabolism and in activating osteoclasts.

In a cell-based test, the team found that IL-20 completely inhibited the formation of osteoclasts from stem cells.

The team then did an experiment on mice showing symptoms of osteoporosis. After the IL-20 antibody was injected into the mice, their bone mineral density increased and they were protected from the low bone density affliction.

Chang said the results indicate that IL-20 is a novel target for the treatment of osteoporosis and that the IL-20 antibody could result in a potent anti-osteoporosis drug.

She said there is already an anti-osteoporosis drug on the market approved by the US Food and Drug Administration, called denosumab, that is an anti-RANKL antibody.

But a drug based on the IL-20 antibody would go beyond that, she said.

"The IL-20 antibody not only blocks the production of IL-20 but also the protein RANKL," Chang said. "If further developed into a therapeutic drug, the IL-20 antibody should have many advantages over denosumab."

According to the professor, a new drug based on the discovery can be marketed in six to 10 years.

The discovery was published in the Journal of Experimental Medicine, a noted international magazine in the field, in September and has drawn widespread attention in the academic community and the biotechnology industry, Chang said.

The chief editor of Nature Reviews wrote a research highlight in the September issue of Nature Reviews Rheumatology commenting on the finding while the Science-Business eXchange published a cover story reporting on the discovery in the same month.

Focustaiwan



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